Set-off is usually evident in areas of the design with very high ink density, such as deep shadows or large areas of solid color coverage. Excessive TIC not only prolongs the drying time, but the mechanical pressure of the delivery pile (the weight of all stacked sheets) compresses the semi-dry ink, facilitating its transfer to the back of the sheet above it. To combat this phenomenon, print shops employ various techniques. One of the most common methods is the use of Anti-Set-off Powder, which is sprayed onto the printed sheet to create a minute air gap between sheets, minimizing direct contact between the ink and the back of the subsequent sheet.

However, the qualitative and preventive solution is precise Color Separation management and TIC reduction during the Prepress stage. Using methods like GCR instead of UCR can reduce the total ink amount by replacing colored inks with Black, drastically lowering the probability of Set-off. Additionally, fine-tuning the ink's drying time relative to the paper type and using accelerating additives in the ink are crucial steps the press operator must consider to prevent this problem.